Alpha-adrenoreceptor blockade with phenoxybenzamine does not affect the ability of the nose to condition air.

نویسندگان

  • Jayant M Pinto
  • Paraya Assanasen
  • Fuad M Baroody
  • Edward Naureckas
  • Robert M Naclerio
چکیده

The primary function of the nose is to warm and humidify air. We have previously shown that raising nasal mucosal temperature by immersing feet in warm water increases the amount of water evaporated by the nose as air passes through it (nasal conditioning capacity; Abbott D, Baroody F, Naureckas E, and Naclerio R. Am J Rhinol 15: 41-45, 2001). To investigate further the effect of nasal mucosal temperature on nasal conditioning capacity, we raised the temperature through alpha-adrenoreceptor blockade by intranasally administering phenoxybenzamine. We hypothesized that blocking alpha-adrenoreceptors during inhalation of cold, dry air would lead to an increase in nasal blood flow, surface temperature, and nasal conditioning capacity, as measured by the water gradient. After appropriate pilot studies, we performed a double-blind, placebo-controlled, two-way crossover study in nine nonatopic, healthy subjects by studying the effect of treatment with intranasal phenoxybenzamine. Nasal mucosal temperature increased significantly after administration of phenoxybenzamine and was associated with a significantly smaller net decrease in nasal mucosal temperature after exposure to cold, dry air (P < 0.05). However, there were no significant differences in nasal conditioning capacity between treatments (P > 0.05). Phenoxybenzamine decreased the symptom of rhinorrhea after exposure to cold, dry air (P < 0.05), but congestion was not different between individuals given phenoxybenzamine and placebo (P > 0.05). Our data demonstrate that phenoxybenzamine, despite raising mucosal temperature and not affecting nasal volume, did not affect the ability of the nose to warm and humidify air.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

-Adrenoreceptor blockade with phenoxybenzamine does not affect the ability of the nose to condition air

Pinto, Jayant M., Paraya Assanasen, Fuad M. Baroody, Edward Naureckas, and Robert M. Naclerio. -Adrenoreceptor blockade with phenoxybenzamine does not affect the ability of the nose to condition air. J Appl Physiol 99: 128–133, 2005. First published March 3, 2005; doi:10.1152/japplphysiol.00857.2004.—The primary function of the nose is to warm and humidify air. We have previously shown that rai...

متن کامل

Pheochromocytoma: a review on preoperative treatment with phenoxybenzamine or doxazosin.

BACKGROUND During surgical treatment of pheochromocytoma,`haemodynamic instability may occur. To prevent this, patients receive preoperative treatment with an alpha-blocker. Nowadays, some centres use phenoxybenzamine, while others use doxazosin. The purpose of this review is to analyse the current evidence of the benefits and risks of phenoxybenzamine and doxazosin in the preoperative treatmen...

متن کامل

Terazosin as First Line Preoperative Blockade in Filipino Patients Diagnosed with Pheochromocytoma

Preoperative blockade in controlling hypertension in patients with pheochromocytoma is essential to improve intraoperative hemodynamic stability and minimize morbidity during resection of the adrenal mass. Phenoxybenzamine, a non-selective alpha adrenergic blocker, has been widely used in blood pressure control for this condition, but is unavailable in the Philippines. Selective alpha-1 antagon...

متن کامل

Control of cerebral vasospasm by parenteral phenoxybenzamine.

Control of Cerebral Vasospasm by Parenteral Phenoxybenzamine • Cerebral vasospasm has been studied in the basilar artery of the cat. The ability of alpha adrenergic blocking agents to prevent and alleviate spasm produced by the application of blood to the basilar artery has been investigated. Parenteral phenoxybenzamine is effective in preventing spasm under these experimental conditions when g...

متن کامل

Effect of TNF-α Blockade in Gingival Crevicular Fluid on Periodontal Condition of Patients with Rheumatoid Arthritis

Background: Periodontitis and rheumatoid arthritis (RA) share a number of clinical and pathologic features, one of which is the presence of the tumor necrosis factor alpha (TNF-α)-induced bone resorption that is involved in the pathogenesis of both. Objectives: To investigate the effect of TNF-α blockade on periodontal conditions in patients with active RA. Method: The periodontal statuses of 3...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of applied physiology

دوره 99 1  شماره 

صفحات  -

تاریخ انتشار 2005